The Western Region serves the following counties in western Missouri: Atchison, Nodaway, Worth, Harrison, Holt, Andrew, Gentry, DeKalb, Daviess, Caldwell, Clinton, Buchanan, Platte, Clay, Ray, Carroll, Jackson, Lafayette, Cass, Johnson, Bates, Henry, and St. Clair. Cities include Kansas City, St. Joseph, Warrensburg, Clinton, Maryville, Harrisonville, Cameron, Richmond, Lexington, and Butler.

The mission of Missouri Right to Life – Western Region is to achieve societal and legal recognition of and respect for the sanctity of human life through all its stages, from the biological beginning of each individual life (whether begun sexually or asexually) through each person's natural death.

The Region seeks changes in public opinion, public policy, the law, and individual behavior through peaceful, legal means. It respects each person’s right to life and rejects abortion, euthanasia, reproductive and therapeutic human cloning, embryonic stem cell research, and other actions that deny this most basic of all human rights.